Genetic Polymorphism of Angiotensin II Type 1 Receptors and Their Effect on the Clinical Outcome of Captopril Treatment in Arab Iraqi Patients with Acute Coronary Syndrome (Mid Euphrates)     

Fadhaa A. Ghafil  Bassim I. Mohammad  Hussain S. Al-Janabi  Najah R. Hadi  Hayder A. Al-Aubaidy 《Indian journal of clinical biochemistry : IJCB》2021,36(1):81

Genetic variation in the angiotensin II type 1 receptor (AT1R) has an important effect on the outcome of acute coronary syndrome (ACS) initiated treatment with captopril. This study aims to investigate the impact of genetic polymorphism of AT1R (rs5186 and rs275651) on the ACS outcome in Iraqi patients treated with captopril. A total of 250 Iraqi individuals with ACS were included in this case—control study and they were divided into two study groups; Study group 1 included 125 participants who were prescribed captopril, 25 mg twice daily and study group 2 included 125 participants who received no captopril as part of their ACS treatment (control study). The AT1R gene (rs5186) CC genotype was found to be associated with ST-elevation myocardial infarction (STEMI) (Odd’s ratio (O.R) = 1.2, P = 0.7), while AC was associated with Non-ST-elevation myocardial infarction (NSTEMI) and unstable angina (UA) (O.R = 1.2, P = 0.8). AC genotype is more prone to have Percutaneous coronary intervention (PCI) after ACS attack (O.R = 1.2, P = 0.6). CC genotype had a risk to get less improvement (O.R = 1.6, P = 0.5), so might require higher doses of captopril during acute coronary insult. The AT1R gene (rs275651) AA genotype was associated with UA (O.R = 1.3, P = 0.9). AA and AT genotypes were more prone to have PCI after ACS attack (O.R = 3.9 P = 0.2, O.R = 3.5, P = 0.3 respectively) and thus requiring higher doses of captopril. We conclude that the AT1R rs5186, rs275651 genetic polymorphisms might partially affect the clinical outcome of ACS patients treated with captopril and might have captopril resistance which requires higher doses.  相似文献   

时间使用流行病学在身体活动研究领域的应用     

宋俊辰  李红娟  王政淞 《体育科学》2020,(1):79-88

身体活动与健康促进是公共卫生及运动科学领域研究的重点方向之一。个体一日24 h由睡眠、久坐及各种强度的身体活动组成,已有研究多从单一维度探讨这些行为对健康的影响,忽视了身体活动、久坐、睡眠等行为之间的内在联系及对健康结果的综合影响,可能使相应行为与健康效应间的关联产生偏差。时间使用流行病学研究方法的引入克服了这一不足。以“时间分配”作为切入点,综述国际学术界关于身体活动、久坐和睡眠行为对健康影响的研究现状,并系统阐述了等时替代研究方法、活动-平衡模型、时间使用流行病学的发展及其研究框架。基于此,展望了时间使用流行病学相关理论在身体活动研究领域的应用前景:1、开发新式测量工具并完善数据收集和分析方法;2、建立有关时间使用模式的综合评价体系;3、制订我国大众人群的活动-平衡时间分配推荐指南方案。  相似文献   

习惯行为、执行意向与青少年身体活动意向与行为:基于计划行为理论的扩展模型     

王丽娟  郑丹蘅 《上海体育学院学报》2020,(2):22-32

在计划行为理论(TPB)的基础上,引入身体活动习惯行为与执行意向,构建扩展TPB(METPB)模型,检验该模型对9~19岁青少年群体的中高强度身体活动(MVPA)的适用性,探讨该模型对小学、初中及高中阶段青少年MVPA影响的差异。结果显示:假设模型的拟合度可以接受,纳入习惯行为与执行意向后,METPB显著地提高了其对身体活动行为的解释力。态度和感知行为控制对MVPA行为意向有显著性影响,解释了31.4%的行为意向方差;行为意向和习惯行为对MVPA行为有显著性影响,解释了18.7%的行为方差;执行意向加强了行为意向朝实际行为的转换。METPB模型对于不同学习阶段青少年MVPA意向及行为的影响有显著性差异。其中:主观规范对小学生与初中生MVPA意向产生了显著性影响,而对高中生的MVPA意向并无显著性影响;感知行为控制对3个阶段学生的MVPA意向产生的影响随着学习阶段的上升不断增强。建议:在对于青少年身体活动的干预中,政府、家庭、学校应重视培养学生对于身体活动参与的正确态度,提高其参与身体活动的意愿,培养其参与身体活动的行为习惯,且在对青少年身体活动干预时考虑学习阶段的差异。  相似文献   

School exclusion,substance misuse and use of weapons: an interpretative phenomenological analysis of interviews with children     

Sarah Martin-Denham 《Support for Learning》2021,36(4):532-554

The study presents data drawn from semi-structured interviews with five young people permanently excluded from schools in North East England. The research aimed to investigate the risk factors that lead to the children using illegal drugs, to determine the drivers and implications for drug misuse and the carrying of knives into school. The research also hoped to elicit from the young people, the solutions that could have prevented their exclusion from school. The interviews were analysed using interpretative phenomenological analysis to understand how a homogenous sample made sense of their lived experiences. The findings highlight the importance of prompt identification and support for children with learning and subsequent mental health needs as the evidence suggests they lead to perceived negative behaviours by teachers. The research provides further evidence that behaviour sanctions in mainstream schools such as detention and isolation booths do not improve behaviour but make it worse. Original to this research is the finding that children are consuming drugs before school to cope with their inability to access the learning, to aid their concentration and to medicate themselves to reduce the likelihood of being sanctioned by teachers.  相似文献   

上海“体教结合”举措下竞技体育后备人才“学生-运动员”双重角色的认同、冲突与转化          下载免费PDF全文

侯爽 《体育科研》2019,(3):30-37

“体教结合”是解决当前我国竞技体育发展问题的重要途径和举措。传统的体育后备人才培养模式只重视专项体育技能的发展而忽视了文化教育的重要性，不利于个体的全面发展。“体教结合”更重视人的全面发展，体育与教育的融合，使得竞技体育人才逐渐从运动员这一单一角色向“学生-运动员”双重角色转变。研究以角色认同为切入口，探讨上海“体教结合”举措下，角色的转变对体育竞技后备人才的影响。选取上海体育学院中国乒乓球学院少年班学员作为“学生-运动员”样本，选取国家乒乓球青年队及部分省市队队员作为职业运动员样本，使用结构化心理测量工具，对比两类受访者在运动与学业上的角色认同、心理倦怠与动机变量的差异。得出：在上海“体教结合”举措下，竞技体育后备人才认同“学生-运动员”双重角色，他们在学业任务中的卷入程度更高；双重角色使运动员在运动任务与学业任务上的主观价值感存在差异，表现出双重角色之间的冲突，但对个体的整体人生规划并不冲突；双重角色之间的转化，对于“学生-运动员”的心理健康存在促进效应。  相似文献   

The carbon footprint of active sport participants     

《Sport Management Review》2019,22(4):513-526

Researchers examining carbon dioxide-equivalent emissions (carbon footprint) in sport have focused on sport events and, to a lesser extent, sport teams, but provided only average or aggregate values. The author takes the perspective of active sport participants and considers the heterogeneity of individual sport participation behavior. Using online surveys, adult active sport participants (n = 6537) in 20 different sports with main residence in Germany were asked to report their sport-travel behavior in 2015, including traveling in the context of regular (weekly) activity, sport competitions/tournaments, league games, day trips, and training camps/vacations. Annual carbon footprints were estimated using information about travel distances and transportation means. The results revealed an average annual carbon footprint of 844 kg of carbon dioxide-equivalent emissions, with individual sports producing more emissions than team/racket sports. Participants in nature sports had the highest emission levels. Regression analyses revealed that environmental consciousness significantly reduced carbon footprint in individual sports, but not in team/racket and nature sports, supporting the existence of an environmental value-action gap. Activity years, club membership, weekly exercise hours, performance level, and income were mainly positively associated with annual carbon footprint, while gender was insignificant. The findings have implications for policy makers and managers in sport associations and clubs.  相似文献   

Nostalgia,homesickness and emotional formation on the eighteenth-century Grand Tour     

Sarah Goldsmith 《Cultural and Social History》2018,15(3):333-360

Nostalgia and homesickness were well-known eighteenth-century ailments. Undertaking protracted travels, Grand Tourists were potential sufferers, yet these emotional afflictions are absent from the Tour's lengthy lists of hazards. Querying this and applying history of emotions approaches to the histories of the Tour, masculinity and the family, this article examines how Tourists and tutors navigated nostalgia and homesickness as emotions that sat uneasily with the Tour's wider aims of masculine formation. Such investigations offer a means of unpicking the complex, contradictory demands placed on young gentlemen during their emotional formation. Through this, it contributes to wider reconsiderations of eighteenth-century masculinity.  相似文献   

The Eton Montem custom c. 1750–1844: privilege,pageantry and sanctioned misrule     

Catherine Dille 《Cultural and Social History》2018,15(3):361-377

Montem, a triennial customary march by Eton scholars, consolidated into a public expression of patrician social identity under the patronage of the monarchy in the late eighteenth century. This analysis of Montem’s history traces its development from a boy-led pageant of misrule to a public performance of elite patriotism. The custom, which attracted national attention, sheds new light on boy governance and self-fashioning in the period’s elite schools. This article argues that a study of Montem disrupts the standard historiographical narrative of anarchy and violence in the great schools and suggests that boy culture was more complex than previously acknowledged.  相似文献   

Reconsidering the use of video clubs for student-teachers' learning during field placement: Lessons drawn from a longitudinal multiple case study     

《Teaching and Teacher Education》2018

Although video clubs have been used to support (student) teachers' learning through reflection upon practice, less attention has been paid to their potential use for supporting changes in participants' practice over a period of time. Prior work has also largely treated (student) teachers as an undifferentiated whole that benefits in similar ways from video clubs. In this study, we problematize this assumption by drawing on three cases of student teachers to exemplify three different learning paths while participating in a video club during field placement. Reflecting on these findings, we discuss implications for differentiating the video-club approach to address different student teachers.  相似文献   

不同负荷运动训练对大鼠骨骼肌线粒体三羧酸循环的影响及其机制研究     

李洁  杨静  赵丽丽 《武汉体育学院学报》2019,53(5):88-94

目的：探讨不同负荷运动训练对大鼠骨骼肌线粒体三羧酸循环的影响及其机制。方法：将雄性Wistar大鼠50只随机均分为5组：安静对照组（C）、低负荷运动训练组（LT）、中等负荷运动训练组（MT）、高负荷运动训练组（HT）和极高负荷运动训练组（ST），每组10只。各运动组分别进行6周的跑台运动训练。训练方案结束后，取腓肠肌样本，提取线粒体，测定线粒体柠檬酸合成酶（CS）、异柠檬酸脱氢酶（ICD）和α-酮戊二酸脱氢酶（α-KGDHC）活性；线粒体Ga²⁺含量、胞浆NADH、NAD⁺、ATP和ADP含量，以及ICD mRNA转录水平。结果：（1）不同负荷运动训练组线粒体CS、ICD和α-KGDHC的活性均显著高于安静对照组（P < 0.01），且CS和ICD活性由高到低顺序均为：MT组 > HT组 > ST组 > LT组 > C组，α-KGDHC活性由高到低顺序为：HT组 > MT组 > ST组 > LT组 > C组。（2）不同负荷运动训练组线粒体Ca²⁺ 含量均显著高于安静对照组（P < 0.01），其含量由高到低顺序为：MT组 > HT组 > ST组 > LT组 > C组；胞浆NADH/NAD⁺和ATP/ADP的比值均显著低于安静对照组（P < 0.01），其比值由低到高顺序为：MT组 < ST组 < HT组 < LT组 < C组。（3）不同负荷运动训练组ICD mRNA转录水平均高于安静对照组（P < 0.01），其水平由高到低顺序为： MT组 > HT组 > ST组 > LT组 > C组。结论：低负荷、中等负荷、高负荷及极高负荷运动训练均可提高大鼠骨骼肌线粒体三羧酸循环功能，且中等负荷运动训练效果最佳。其机制与胞浆NADH/NAD⁺和ATP/ADP比值、线粒体摄钙能力及限速酶基因的表达有关。  相似文献